Anyone who has lived in the BC must have ridden the Duffy! If not you are a fool. Same goes for you down there in Washington. The Duffy is an epic ride, maybe one of the best in BC, Especially since the road from Vancouver to Whistler has been upgraded AND they have paved about half of the road from Pemberton to Lillooet. The new paved section is amazing (hopefully it survived the winter) but watch out when you hit the old road, it's a little abrupt at first. A big thankyou to 2010 Olympics for the road upgrades.
If your a local, you can ride the Duffy in a day (a long day) or better yet make it 2 and camp at one of many free Forestry campsites along the Duffy
When in Lillooet stop at the Reynolds Hotel for Breakfast/Lunch. Their was a waitress there that could remember everything ordered no matter how many of you went in. She was amazing.
We even stayed overnight there once. Really nice rooms, pretty cheap, Beer store and bar downstairs, they even let us park our bikes in the covered secure loading bay!
The Fraser Canyon is a beautiful road as well, make your trip longer and go through Cache Creek and stop at The Log Cabin in Spences Bridge. Cool Biker bar. There is no gas in Spences Bridge so make sure you got gas either in Cache Creek or Lytton. (I had to buy gas off of a one armed lady who lived next to the graveyard and sold gas out of her garage!)
There are a bunch of variations you can do in the area. BC is best!
Here's some pics Scott Pommier took of a Duffy ride we did back in 07 (as seen in Street Chopper awhile back)